Genestra Brands
Hmb Complex (310 G)
$66.50
HMB Complex: Calcium beta-hydroxy beta-methylbutyrate + glutamine, arginine, and BCAAs • May help support a modest improvement in exercise capacity in individuals with stable cardiovascular disease • Improves muscle strength in previously untrained individuals, when combined with intense resistance exercise • Provides essential branched-chain amino acids (leucine, isoleucine, valine) involved in protein synthesis • Delivers 500 IU of vitamin D per serving The HMB Complex combines beta-hydroxy beta-methylbutyrate (HMB) with two amino acids (glutamine and arginine) involved in muscle protein synthesis, and three essential branched-chain amino acids (BCAAs), leucine, isoleucine, and valine. HMB is a leucine metabolite that is naturally formed in the body.1 A 70 kg individual produces approximately 0.2-0.4 g of HMB per day.2 HMB upregulates protein synthesis in muscle cells, stabilizes muscle cell membranes, and decreases skeletal muscle protein degradation.1, 3-7 When combined with regular physical training, HMB supplementation helps to increase both lean body mass and muscle strength.8,9 The effects of HMB on muscle mass may depend on vitamin D status; in older participants, supplementation with an HMB/arginine/lysine blend only improved muscle strength in participants with normal serum vitamin D levels (less than 30 ng/mL).10 REFERENCES 1. Wilson G, Wilson J, & Manninen A. Nutrition & Metabolism 2008, 5:1 2. Pimentel GD, Rosa JC, Lira FS, Zanchi NE, Ropelle ER, Oyama LM et al. Nutrition & Metabolism, 2011, 8:11 3. Nissen SL, Abumrad NN. J Nutr Biochem. 1997, 8:300-311 4. Eley HL, Russell ST, Tisdale MJ. Am J Physiol Endocrinol Metab. 2008, 295:E1409-E1416 5. Eley HL, Russell ST, Tisdale MJ. Am J Physiol Endocrinol Metab. 2008, 295:E1417-E1426 6. Yeh SS, Blackwood K, Schuster MW. J Am Med Dir Assoc. 2008, 9:219-236 7. Kornasio R, Riederer I, Butler-Browne G, Mouly V, Uni Z, Halevy O. Biochim Biophys Acta. 2009, 1793:755-763 8. Stout J, Smith-Ryan A, Fukuda D, Kendall K, Moon J, Hoffman J, Wilson J, Oliver J, & Mustad V. Experimental Gerontology. 2013, 48:1303-1310 9. Gallagher P, Carrithers J, Godard M, Schulze K, & Trappe S. Medicine & Science in Sports & Exercise. 2000, 32(12):2109-2115 10. Fuller J, Baier S, Flakoll P, Nissen S, Abumrad N, & Rathmacher J. Journal of Parenteral and Enteral Nutrition, 2011, 35(6):757-762
