Methylation Support (90 Capsules)

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Vegetarian-friendly B vitamin complex • Helps the body metabolize carbohydrates, fats and proteins • Helps in tissue and red blood cell formation • Provides 50 mg of vitamin B6, 801 mcg of vitamin B12 and 400 mcg of folate (from Metafolin®) daily • Helps prevent vitamin B6, vitamin B12 and folate deficiency Methylation Support provides a combination of B vitamins, choline and betaine to help support homocysteine levels.1 Homocysteine is an amino acid that can be metabolized into either methionine or cysteine.1 Normal homocysteine levels are important for nucleic acid, protein and lipid methylation, as well as protein production.1 A randomized, double-blind trial involving 76 adults demonstrated that supplementation with 1.5 g of betaine per day for six weeks significantly maintained homocysteine levels compared to a placebo.2 Betaine also helps to support liver function by stimulating the production and export of very low-density lipoproteins (VLDL) from the liver.3 Methylation Support contains the physiologically active forms of vitamin B6, folate and vitamin B12, B vitamins involved in tissue formation, red blood cell formation and macromolecule metabolism, respectively.4 Due to their interdependent pathways, it is important to have metabolic balances between choline, betaine, homocysteine, vitamin B6, vitamin B12 and folate.5 REFERENCES 1. Selhub, J. Nutrition Reviews. 2008, 29(2 Suppl): S116 to S125. 2. Olthof, MR, van Vliet, T, Boelsma, E, Verhoef, P. J. Nutr. 2003, 133: 4135-4138. 3. Craig, SAS. Am J Clin Nutr. 2004, 80: 539-549. 4. Combs, GF. (2012). The Vitamins (4th ed.). USA: Elsevier. 5. Michel, V, Yuan, Z, Ramsubir, S, Bakovic, M. Exp Biol Med. 2006, 231: 490-504.